GrippeCanadaV3, Main, Exploration, bibRecord, 000275

Immune biomarkers predictive of respiratory viral infection in elderly nursing home residents.

Identifieur interne : 000275 ( Main/Exploration ); précédent : 000274; suivant : 000276

Immune biomarkers predictive of respiratory viral infection in elderly nursing home residents.

Auteurs : Jennie Johnstone [Canada] ; Robin Parsons [Canada] ; Fernando Botelho [Canada] ; Jamie Millar [Canada] ; Shelly Mcneil [Canada] ; Tamas Fulop [Canada] ; Janet Mcelhaney [Canada] ; Melissa K. Andrew [Canada] ; Stephen D. Walter [Canada] ; P J Devereaux [Canada] ; Mehrnoush Malekesmaeili [Canada] ; Ryan R. Brinkman [Canada] ; James Mahony [Canada] ; Jonathan Bramson [Canada] ; Mark Loeb [Canada]

Source :

PloS one [ 1932-6203 ] ; 2014.

RBID : pubmed:25275464

Descripteurs français

KwdFr :
- Analyse multivariée, Canada, Cytomegalovirus (immunologie), Facteurs temps, Femelle, Humains, Infections de l'appareil respiratoire (immunologie), Infections de l'appareil respiratoire (virologie), Infections à cytomégalovirus (immunologie), Lymphocytes T (immunologie), Maisons de repos, Marqueurs biologiques (métabolisme), Mâle, Phénotype, Sujet âgé, Sujet âgé de 80 ans ou plus, Études de cohortes.
MESH :
- immunologie : Cytomegalovirus, Infections de l'appareil respiratoire, Infections à cytomégalovirus, Lymphocytes T.
- métabolisme : Marqueurs biologiques.
- virologie : Infections de l'appareil respiratoire.
- Analyse multivariée, Canada, Facteurs temps, Femelle, Humains, Maisons de repos, Mâle, Phénotype, Sujet âgé, Sujet âgé de 80 ans ou plus, Études de cohortes.
Wicri :
- geographic : Canada.

English descriptors

KwdEn :
- Aged, Aged, 80 and over, Biomarkers (metabolism), Canada, Cohort Studies, Cytomegalovirus (immunology), Cytomegalovirus Infections (immunology), Female, Humans, Male, Multivariate Analysis, Nursing Homes, Phenotype, Respiratory Tract Infections (immunology), Respiratory Tract Infections (virology), T-Lymphocytes (immunology), Time Factors.
MESH :
- chemical , metabolism : Biomarkers.
- geographic : Canada.
- immunology : Cytomegalovirus, Cytomegalovirus Infections, Respiratory Tract Infections, T-Lymphocytes.
- virology : Respiratory Tract Infections.
- Aged, Aged, 80 and over, Cohort Studies, Female, Humans, Male, Multivariate Analysis, Nursing Homes, Phenotype, Time Factors.

Abstract

OBJECTIVE

To determine if immune phenotypes associated with immunosenescence predict risk of respiratory viral infection in elderly nursing home residents.

METHODS

Residents ≥ 65 years from 32 nursing homes in 4 Canadian cities were enrolled in Fall 2009, 2010 and 2011, and followed for one influenza season. Following influenza vaccination, peripheral blood mononuclear cells (PBMCs) were obtained and analysed by flow cytometry for T-regs, CD4+ and CD8+ T-cell subsets (CCR7+CD45RA+, CCR7-CD45RA+ and CD28-CD57+) and CMV-reactive CD4+ and CD8+ T-cells. Nasopharyngeal swabs were obtained and tested for viruses in symptomatic residents. A Cox proportional hazards model adjusted for age, sex and frailty, determined the relationship between immune phenotypes and time to viral infection.

RESULTS

1072 residents were enrolled; median age 86 years and 72% female. 269 swabs were obtained, 87 were positive for virus: influenza (24%), RSV (14%), coronavirus (32%), rhinovirus (17%), human metapneumovirus (9%) and parainfluenza (5%). In multivariable analysis, high T-reg% (HR 0.41, 95% CI 0.20-0.81) and high CMV-reactive CD4+ T-cell% (HR 1.69, 95% CI 1.03-2.78) were predictive of respiratory viral infection.

CONCLUSIONS

In elderly nursing home residents, high CMV-reactive CD4+ T-cells were associated with an increased risk and high T-regs were associated with a reduced risk of respiratory viral infection.

DOI: 10.1371/journal.pone.0108481
PubMed: 25275464

Affiliations:

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Le document en format XML

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<author><name sortKey="Andrew, Melissa K" sort="Andrew, Melissa K" uniqKey="Andrew M" first="Melissa K" last="Andrew">Melissa K. Andrew</name>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Aged, 80 and over</term>
<term>Biomarkers (metabolism)</term>
<term>Canada</term>
<term>Cohort Studies</term>
<term>Cytomegalovirus (immunology)</term>
<term>Cytomegalovirus Infections (immunology)</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Multivariate Analysis</term>
<term>Nursing Homes</term>
<term>Phenotype</term>
<term>Respiratory Tract Infections (immunology)</term>
<term>Respiratory Tract Infections (virology)</term>
<term>T-Lymphocytes (immunology)</term>
<term>Time Factors</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Analyse multivariée</term>
<term>Canada</term>
<term>Cytomegalovirus (immunologie)</term>
<term>Facteurs temps</term>
<term>Femelle</term>
<term>Humains</term>
<term>Infections de l'appareil respiratoire (immunologie)</term>
<term>Infections de l'appareil respiratoire (virologie)</term>
<term>Infections à cytomégalovirus (immunologie)</term>
<term>Lymphocytes T (immunologie)</term>
<term>Maisons de repos</term>
<term>Marqueurs biologiques (métabolisme)</term>
<term>Mâle</term>
<term>Phénotype</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Études de cohortes</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Biomarkers</term>
</keywords>
<keywords scheme="MESH" type="geographic" xml:lang="en"><term>Canada</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Cytomegalovirus</term>
<term>Infections de l'appareil respiratoire</term>
<term>Infections à cytomégalovirus</term>
<term>Lymphocytes T</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Cytomegalovirus</term>
<term>Cytomegalovirus Infections</term>
<term>Respiratory Tract Infections</term>
<term>T-Lymphocytes</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Marqueurs biologiques</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections de l'appareil respiratoire</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Respiratory Tract Infections</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Aged, 80 and over</term>
<term>Cohort Studies</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Multivariate Analysis</term>
<term>Nursing Homes</term>
<term>Phenotype</term>
<term>Time Factors</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Analyse multivariée</term>
<term>Canada</term>
<term>Facteurs temps</term>
<term>Femelle</term>
<term>Humains</term>
<term>Maisons de repos</term>
<term>Mâle</term>
<term>Phénotype</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Études de cohortes</term>
</keywords>
<keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Canada</term>
</keywords>
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</teiHeader>
<front><div type="abstract" xml:lang="en"><p><b>OBJECTIVE</b>
</p>
<p>To determine if immune phenotypes associated with immunosenescence predict risk of respiratory viral infection in elderly nursing home residents.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>METHODS</b>
</p>
<p>Residents ≥ 65 years from 32 nursing homes in 4 Canadian cities were enrolled in Fall 2009, 2010 and 2011, and followed for one influenza season. Following influenza vaccination, peripheral blood mononuclear cells (PBMCs) were obtained and analysed by flow cytometry for T-regs, CD4+ and CD8+ T-cell subsets (CCR7+CD45RA+, CCR7-CD45RA+ and CD28-CD57+) and CMV-reactive CD4+ and CD8+ T-cells. Nasopharyngeal swabs were obtained and tested for viruses in symptomatic residents. A Cox proportional hazards model adjusted for age, sex and frailty, determined the relationship between immune phenotypes and time to viral infection.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>RESULTS</b>
</p>
<p>1072 residents were enrolled; median age 86 years and 72% female. 269 swabs were obtained, 87 were positive for virus: influenza (24%), RSV (14%), coronavirus (32%), rhinovirus (17%), human metapneumovirus (9%) and parainfluenza (5%). In multivariable analysis, high T-reg% (HR 0.41, 95% CI 0.20-0.81) and high CMV-reactive CD4+ T-cell% (HR 1.69, 95% CI 1.03-2.78) were predictive of respiratory viral infection.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b>
</p>
<p>In elderly nursing home residents, high CMV-reactive CD4+ T-cells were associated with an increased risk and high T-regs were associated with a reduced risk of respiratory viral infection.</p>
</div>
</front>
</TEI>
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<DateCompleted><Year>2015</Year>
<Month>06</Month>
<Day>10</Day>
</DateCompleted>
<DateRevised><Year>2018</Year>
<Month>11</Month>
<Day>13</Day>
</DateRevised>
<Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Electronic">1932-6203</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>9</Volume>
<Issue>9</Issue>
<PubDate><Year>2014</Year>
</PubDate>
</JournalIssue>
<Title>PloS one</Title>
<ISOAbbreviation>PLoS ONE</ISOAbbreviation>
</Journal>
<ArticleTitle>Immune biomarkers predictive of respiratory viral infection in elderly nursing home residents.</ArticleTitle>
<Pagination><MedlinePgn>e108481</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1371/journal.pone.0108481</ELocationID>
<Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To determine if immune phenotypes associated with immunosenescence predict risk of respiratory viral infection in elderly nursing home residents.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">Residents ≥ 65 years from 32 nursing homes in 4 Canadian cities were enrolled in Fall 2009, 2010 and 2011, and followed for one influenza season. Following influenza vaccination, peripheral blood mononuclear cells (PBMCs) were obtained and analysed by flow cytometry for T-regs, CD4+ and CD8+ T-cell subsets (CCR7+CD45RA+, CCR7-CD45RA+ and CD28-CD57+) and CMV-reactive CD4+ and CD8+ T-cells. Nasopharyngeal swabs were obtained and tested for viruses in symptomatic residents. A Cox proportional hazards model adjusted for age, sex and frailty, determined the relationship between immune phenotypes and time to viral infection.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">1072 residents were enrolled; median age 86 years and 72% female. 269 swabs were obtained, 87 were positive for virus: influenza (24%), RSV (14%), coronavirus (32%), rhinovirus (17%), human metapneumovirus (9%) and parainfluenza (5%). In multivariable analysis, high T-reg% (HR 0.41, 95% CI 0.20-0.81) and high CMV-reactive CD4+ T-cell% (HR 1.69, 95% CI 1.03-2.78) were predictive of respiratory viral infection.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">In elderly nursing home residents, high CMV-reactive CD4+ T-cells were associated with an increased risk and high T-regs were associated with a reduced risk of respiratory viral infection.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Johnstone</LastName>
<ForeName>Jennie</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Parsons</LastName>
<ForeName>Robin</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>McMaster Immunology Research Centre, McMaster University, Hamilton, Ontario, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Botelho</LastName>
<ForeName>Fernando</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>McMaster Immunology Research Centre, McMaster University, Hamilton, Ontario, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Millar</LastName>
<ForeName>Jamie</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>McMaster Immunology Research Centre, McMaster University, Hamilton, Ontario, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>McNeil</LastName>
<ForeName>Shelly</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Canadian Center for Vaccinology, IWK Health Centre and Capital Health, Dalhousie University, Halifax, Nova Scotia, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Fulop</LastName>
<ForeName>Tamas</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Department of Medicine, Geriatrics Division, Research Center on Aging, University of Sherbrooke, Sherbrooke, Quebec, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>McElhaney</LastName>
<ForeName>Janet</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Department of Medicine, Northern Ontario School of Medicine, Sudbury, Ontario, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Andrew</LastName>
<ForeName>Melissa K</ForeName>
<Initials>MK</Initials>
<AffiliationInfo><Affiliation>Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Walter</LastName>
<ForeName>Stephen D</ForeName>
<Initials>SD</Initials>
<AffiliationInfo><Affiliation>Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Devereaux</LastName>
<ForeName>P J</ForeName>
<Initials>PJ</Initials>
<AffiliationInfo><Affiliation>Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada; Department of Medicine, McMaster University, Hamilton, Ontario, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Malekesmaeili</LastName>
<ForeName>Mehrnoush</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, British Columbia, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Brinkman</LastName>
<ForeName>Ryan R</ForeName>
<Initials>RR</Initials>
<AffiliationInfo><Affiliation>Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, British Columbia, Canada; Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mahony</LastName>
<ForeName>James</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada; Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bramson</LastName>
<ForeName>Jonathan</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>McMaster Immunology Research Centre, McMaster University, Hamilton, Ontario, Canada; Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada; Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Loeb</LastName>
<ForeName>Mark</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada; Department of Medicine, McMaster University, Hamilton, Ontario, Canada; Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada; Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>R01 EB008400</GrantID>
<Acronym>EB</Acronym>
<Agency>NIBIB NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>R01 EB008400/EB/NIBIB</GrantID>
<Acronym>EB</Acronym>
<Agency>NIBIB NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><Agency>Canadian Institutes of Health Research</Agency>
<Country>Canada</Country>
</Grant>
</GrantList>
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<PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
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<ArticleDate DateType="Electronic"><Year>2014</Year>
<Month>10</Month>
<Day>02</Day>
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<MedlineTA>PLoS One</MedlineTA>
<NlmUniqueID>101285081</NlmUniqueID>
<ISSNLinking>1932-6203</ISSNLinking>
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<MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName>
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<MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName>
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<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
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<MeshHeading><DescriptorName UI="D002170" MajorTopicYN="N" Type="Geographic">Canada</DescriptorName>
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<MeshHeading><DescriptorName UI="D015331" MajorTopicYN="N">Cohort Studies</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D003587" MajorTopicYN="N">Cytomegalovirus</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D003586" MajorTopicYN="N">Cytomegalovirus Infections</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015999" MajorTopicYN="N">Multivariate Analysis</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009735" MajorTopicYN="Y">Nursing Homes</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010641" MajorTopicYN="N">Phenotype</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012141" MajorTopicYN="N">Respiratory Tract Infections</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013601" MajorTopicYN="N">T-Lymphocytes</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013997" MajorTopicYN="N">Time Factors</DescriptorName>
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<ArticleIdList><ArticleId IdType="pubmed">22205730</ArticleId>
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</Reference>
<Reference><Citation>Vaccine. 2012 Mar 9;30(12):2060-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22289511</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS Pathog. 2012;8(12):e1003076</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23271970</ArticleId>
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<affiliations><list><country><li>Canada</li>
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<settlement><li>Hamilton (Ontario)</li>
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<orgName><li>Université McMaster</li>
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<tree><country name="Canada"><region name="Ontario"><name sortKey="Johnstone, Jennie" sort="Johnstone, Jennie" uniqKey="Johnstone J" first="Jennie" last="Johnstone">Jennie Johnstone</name>
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<name sortKey="Andrew, Melissa K" sort="Andrew, Melissa K" uniqKey="Andrew M" first="Melissa K" last="Andrew">Melissa K. Andrew</name>
<name sortKey="Botelho, Fernando" sort="Botelho, Fernando" uniqKey="Botelho F" first="Fernando" last="Botelho">Fernando Botelho</name>
<name sortKey="Bramson, Jonathan" sort="Bramson, Jonathan" uniqKey="Bramson J" first="Jonathan" last="Bramson">Jonathan Bramson</name>
<name sortKey="Brinkman, Ryan R" sort="Brinkman, Ryan R" uniqKey="Brinkman R" first="Ryan R" last="Brinkman">Ryan R. Brinkman</name>
<name sortKey="Devereaux, P J" sort="Devereaux, P J" uniqKey="Devereaux P" first="P J" last="Devereaux">P J Devereaux</name>
<name sortKey="Fulop, Tamas" sort="Fulop, Tamas" uniqKey="Fulop T" first="Tamas" last="Fulop">Tamas Fulop</name>
<name sortKey="Loeb, Mark" sort="Loeb, Mark" uniqKey="Loeb M" first="Mark" last="Loeb">Mark Loeb</name>
<name sortKey="Mahony, James" sort="Mahony, James" uniqKey="Mahony J" first="James" last="Mahony">James Mahony</name>
<name sortKey="Malekesmaeili, Mehrnoush" sort="Malekesmaeili, Mehrnoush" uniqKey="Malekesmaeili M" first="Mehrnoush" last="Malekesmaeili">Mehrnoush Malekesmaeili</name>
<name sortKey="Mcelhaney, Janet" sort="Mcelhaney, Janet" uniqKey="Mcelhaney J" first="Janet" last="Mcelhaney">Janet Mcelhaney</name>
<name sortKey="Mcneil, Shelly" sort="Mcneil, Shelly" uniqKey="Mcneil S" first="Shelly" last="Mcneil">Shelly Mcneil</name>
<name sortKey="Millar, Jamie" sort="Millar, Jamie" uniqKey="Millar J" first="Jamie" last="Millar">Jamie Millar</name>
<name sortKey="Parsons, Robin" sort="Parsons, Robin" uniqKey="Parsons R" first="Robin" last="Parsons">Robin Parsons</name>
<name sortKey="Walter, Stephen D" sort="Walter, Stephen D" uniqKey="Walter S" first="Stephen D" last="Walter">Stephen D. Walter</name>
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Immune biomarkers predictive of respiratory viral infection in elderly nursing home residents.

Immune biomarkers predictive of respiratory viral infection in elderly nursing home residents.

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